Izinto ezilungileyo zeCapsule

Kwi-1500 BC, i-capsule yokuqala yazalwa eYiputa.

Ngomnyaka we-1730, oosokhemesti eVienna baqala ukwenza iicapsules kwistatshi.

Ngomnyaka we-1834, iteknoloji yokuvelisa i-capsule yayinelungelo elilodwa lomenzi eParis.

Ngo-1846, iteknoloji yokuvelisa i-capsule enzima yamacandelo amabini yafunyanwa e-France Patents.

Ngowe-1848, ii-capsules ezinamaqhekeza amabini zaphuma. Ukusukela ngoko ukuya phambili, i-Empty hard capsule shells zangena kwihlabathi lezonyango kwaye zaba zizikhongozeli zokupakisha zamayeza.

Kwi-1874, ukuveliswa kwemizi-mveliso yee-capsules ezinzima (Hubel) kwaqalwa eDetroit, kwaye iimodeli ezahlukeneyo zaziswa ngexesha elinye.

Ngo-1888, uParke-Davis wafumana ilungelo elilodwa lomenzi wechiza ukwenza iicapsules ezinzima eDetroit (JB Russell)

Ngomnyaka we-1931, isantya sokuvelisa i-capsule ye-Parke-Davis yafikelela kwi-10,000 capsules ngeyure (A. Colton)

Njengomathiriyeli ofanelekileyo wokupakisha amayeza, iigobolondo ze-capsule ezinzima ezingenanto zisetyenziswa ngokubanzi kumalungiselelo amayeza. Ikakhulu isasazwa ngomgubo, ulwelo, i-semi-solid, i-ointment, iipilisi kunye namanye amalungiselelo. Zinokukhawuleza, zithembeke kwaye ziboliswe ngokukhuselekileyo. Baneenzuzo ezilandelayo:

1) Ubuhle obuhle kwaye kulula ukuginya.

2) I-Masking effect: Iyakwazi ukufihla ubukrakra obungathandekiyo kunye nevumba lechiza, kwaye ikhusele kwaye izinze imixholo engazinzanga.

I-3) I-bioavailability ephezulu yeziyobisi: Iipilisi azifuni ukunamathela kunye noxinzelelo ngexesha lokulungiselela njengamacwecwe kunye neepilisi, ngoko zihlakazeka ngokukhawuleza kwaye zifake kakuhle kwisisu namathumbu.

I-4) Ukukhuselwa okungcono kweemveliso zemithi: Ngaphandle kokushisa okuphezulu kunye noxinzelelo oluphezulu olulethwa yi-tablet press, imeko yendalo yezityalo zonyango kwi-capsule inokugcinwa.

5) Ingenziwa kumalungiselelo okukhululwa okuzinzileyo kunye namalungiselelo adibeneyo:

Ichiza linokukhutshwa ngexesha kunye nendawo (i-enteric-coated, pulsed kunye nezinye iinkqubo zokukhululwa kweziyobisi). Ukuba iyeza lenziwe kuqala libe ngamasuntswana, kwaye emva koko i-gelatin izinto eziluhlaza kunye nezixhobo ezinamazinga ahlukeneyo okukhululwa zisetyenzisiweyo, umphumo wexesha kunye nokukhululwa kwendawo kunokufezekiswa. Ke ngoko, ii-capsules ziifomu ezifanelekileyo zedosi kuphuhliso lwamalungiselelo okukhutshwa okuzinzileyo kunye namalungiselelo adibeneyo.

I-6) Umyalelo kunye nenkqubo yokulungiselela ilula, ilungele ushishino kunye neMveliso ye-automation.