Iindidi ezahlukeneyo zeCollagen kunye nendlela yokuzisebenzisa

Emizimbeni yabantu, i-collagen ibaluleke njengentliziyo emzimbeni wethu. Isinceda sihlale siselula kwaye sisempilweni. Xa sizalwa, i-collagen iphezulu, kodwa njengoko sikhula, ukusilela kwe-collagen kwenzeka, kwaye sikhula. Nangona kunjalo, ukuguga kunokuthotywa ngokuthatha izongezo ze-collagen. Kodwa ingxaki apha kukho iindidi ezingama-28 zeCollagen emzimbeni wethu, kwaye kubaluleke kakhulu ukuba siqonde ukuba loluphi uhlobo esenza ntoni ukuze singagqithisi kolunye uhlobo. Ngoko ke, qhubeka ufunda ukuze uzigcine umncinci kwaye usempilweni.

Umfanekiso-no-1-Iintlobo-ze-Collagen

➔ Uluhlu lokukhangela

1.Yintoni iCollagen?
2.Isebenza njani iCollagen eMzimbeni?
3.Iintlobo ngeentlobo zeCollagen: Zeziphi Iintlobo ezahlukeneyo?

1) Yintoni iCollagen?

Kanye njengokuba iinwele zethu zikhula ngokwemvelo, iCollagen yiproteni eyenziwa ngumzimba wethu rhoqo.

Umzobo akukho 2-yintoni-i-collagen

Kuyamangalisa ukuqaphela ukuba emzimbeni womntu, malunga ne-30% yeprotheyini ye-Collagen, kwaye xa kuthelekiswa nobunzima bomzimba wonke, iiprotheni zenza i-14 ~ 16%. I-Collagen ikhona kuyo yonke indawo, kanye njengomoya eMhlabeni; umzekelo, ungayifumana kumalungu, amathumbu, amathambo, ulusu, kunye nawo onke amanye amalungu omzimba womntu.

2) I-Collagen yenza ntoni emzimbeni?

Ezi zilandelayo ziindima zeCollagen emzimbeni wethu:

Umfanekiso we-3 Yintoni indima ye-collagen emzimbeni.

✓ Elusu - lugcina luthambile, lunwebeka, lomelele, kwaye lungenamibimbi.

✓ Umaleko ongaphezulu kumalungu & namathumbu - sebenza njengomaleko okhuselayo

✓ Ngaphakathi kwamathambo - inceda ekwakhekeni kwamathambo, inyusa ukuxinana, kwaye icothisa i-osteoporosis

✓ KuMajoyinti - anceda ekwenziweni kwawo xa esebenza njengeendawo zokuncamathela kunye nezinto ezifunxa ukothuka

✓ Izikhonkwane - ICollagen yenza ikeratin, ethi emva koko yenze iinzipho. Ke, iCollagen inoxanduva lokukhula kwezipikili kunye nempilo

✓ Iinwele - Iprotein yokuqala, ikeratin, kwizinwele, ivela kwi-amino acid ye-Collagen, ngoko ke, i-Collagen yenza iinwele. Ngaphezu koko, i-dermis layer, apho iifollicle zeenwele (iingcambu) zikhona, ubukhulu becala zenziwe ngeCollagen.

✓ Imithambo yegazi - Iifibers zeCollagen zikhona ngaphantsi kwemithambo yegazi engaphakathi ngendlela yothungelwano. Ngaphezu koko, babonelela ngenkxaso yesakhiwo, kwaye ngexesha lokwenzakala, basebenza njengemagnethi yeearhente zokuphilisa kunye nokunceda ukulungisa.

✓ Phakathi kwemigca yezihlunu - sebenza njengeglu kwizihlunu, uzigcine zidityanisiwe kwaye zinike ukunwebeka kwezicubu. Ziphinde zisebenze njengento ephakathi ukuhambisa amandla e-contractile ukusuka kwimisipha ukuya kwi-skeleton (amathambo, i-tendon, i-ligaments).

3) Zeziphi iintlobo ezahlukeneyo zeCollagen?

Umfanekiso we-4-Ziziphi-iintlobo-ezahlukeneyo-ze-Collagen

Izazinzulu ziye zafumanisa ngaphezulu kwe-28 yeentlobo ze-Collagen kwaye zihlelwa ngokusekwe kwizinto zazo zokwakha, ulungiselelo lwesakhiwo, kunye nemisebenzi eziyenzayo.

Kwezi ntlobo zingama-28, kukho ii-Collagens ezi-5 ezineempembelelo ezininzi, ezinje;

a) Uhlobo lweCollagen I (yeyona ininzi)

b) Uhlobo lweCollagen II

c) Uhlobo lweCollagen III ( luninzi kakhulu)

d) Uhlobo lweCollagen V

e) Uhlobo lweCollagen X

a) Uhlobo I-Collagen kunye nosetyenziso lwayo

"Uhlobo I-Collagen yiprotheni ende, ene-triple-helical, kwaye yenziwe ngama-amino acids amathathu: i-glycine, i-proline, kunye ne-hydroxyproline. Iintsalela ze-glycine zenza undoqo we-triple helix, ngelixa i-proline kunye ne-hydroxyproline intsalela inika ukuguquguquka kunye namandla."

Unokuqikelela ukubaluleka kohlobo lwe-Collagen ukusuka kwindawo ye-1 kwisigaba samagama ngenxa yokuba iqukethe i-90% yazo zonke i-Collagen emzimbeni womntu, ngokukodwa kwesikhumba, amathambo, kunye nezicubu ezidibeneyo (i-tendon, ligaments, cartilage).

➔ Ukusetyenziswa kohlobo I-Collagen

Njengoko Uhlobo lwe-Collagen luninzi kwesikhumba kunye namathambo, unokuqikelela ukuba umsebenzi walo oyintloko kukugcina ulusu luncinci kunye nokugcina amandla amathambo - iinkcukacha zazo zinikwe ngezantsi;

✓ Impilo yolusu: Ukuba unemibimbi, uburhabaxa, okanye uburhabaxa eluswini lwakho, ke eyona ngxaki inkulu kukunqongophala kohlobo lwe-Collagen.

✓ Ukuqhawuka kwemisipha: Uhlobo lwe-Collagen I-Collagen nayo ibalulekile ekunciphiseni kwemisipha. Inceda ukudibanisa imicu yezihlunu kwaye ivumela ukuba yenze isivumelwano kwaye iphumle.

✓ Ukubunjwa kwemithambo yegazi: Uhlobo lwe-Collagen lwe-I lukwabalulekile ekwenzeni imithambo yegazi. Inceda ukwenza iindonga zemithambo yegazi kwaye igcine yomelele kwaye isempilweni.

✓ Ukuphiliswa kwenxeba: Uhlobo I-Collagen nayo ibalulekile ekunyangeni kwenxeba. Inceda ukwenza ukhwekhwe phezu kwenxeba kwaye inika isakhelo sokukhula kwezicubu ezintsha.

✓ Ukulungiswa kweCartilage: Amalungu emzimbeni womntu enziwe ngento ethambileyo ebizwa ngokuba yicartilage, kwaye le cartilage yenziwe ikakhulu ngoType I Collagen. ICartilage isebenza njengento yokutsala ukothuka kunye nendawo yokunciphisa ukukhuhlana phakathi kwamathambo amabini.

✓ Ukwakheka kwamathambo: Ngaphandle kwamathambo, sifana nelaphu elide elilele phantsi. Umzimba wethu uvelisa amathambo ubukhulu becala kuhlobo lwe-collagen ye-I. Ke, ngakumbi Uhlobo lwe-Collagen luthetha ukuveliswa kwamathambo okungcono, ukuphiliswa ngokukhawuleza, kunye nesakhiwo samathambo esomeleleyo.

b) Uhlobo II Collagen & Usetyenziso lwayo

Udidi lwe-II Collagen lwenziwe ngamatyathanga amathathu amade e-amino acids adityaniswe kunye ukuze enze i-triple helix. I-triple helix inikeza uhlobo lwe-II amandla e-Collagen kunye nokuguquguquka.

Ikhoyo ininzi kakhulu kwi-cartilage edibeneyo kwaye inoxanduva lokuhambisa ukomelela kunye nokuguquguquka. Uhlobo II izongezo zeCollagen ziqhele ukwenziwa kwinkukhu okanye kwinyama yenkomo.

➔ Ukusetyenziswa koHlobo lwe-II Collagen

✓ Impilo edibeneyo: Uhlobo lwe-II I-Collagen luninzi kakhulu kwi-cartilage, ngoko kuyavakala ukuba ukuthatha izongezo zayo kuya kunceda ukunyanga izifo zamathambo & zamalungu njenge-osteoarthritis, njl.

✓ Impilo yesikhumba: Olunye uphando lubonise ukuba uhlobo lwe-II Izongezelelo ze-Collagen zinokunciphisa ukubonakala kwemibimbi kunye namabala obudala kunye nokunceda ukuphucula ukuqina kwesikhumba.

✓ Impilo yamathumbu: Ezinye izifundo zophando zibonise ukuba uhlobo lwe-II I-Collagen supplements lunokunceda ukukhusela indawo yangaphakathi / yangaphandle yamathumbu kunye nokuphucula ukugaya kunye nokufunxa izondlo.

✓ Umsebenzi we-immune system: Uhlobo lwe-II Izongezo ze-Collagen nazo ngamanye amaxesha zisetyenziselwa ukunceda amajoni omzimba ukulwa nezifo, okukhokelela ekuchacheni ngokukhawuleza kwizifo.

c) Uhlobo lwe-III Collagen kunye nosetyenziso lwayo

"Ngokwesakhiwo, uhlobo lwe-III Collagen lwenziwa ngamatyathanga amathathu afanayo e-alpha, iyenza i-homotrimer, ngokungafaniyo noHlobo lwe-Collagen, olunamatyathanga amabini e-alpha1 kunye nekhonkco elinye le-alpha2."

Xa kuziwa kuHlobo lwe-III i-collagen, ludidi lwe-2 luninzi lwe-Collagen kumzimba womntu. Isasazwa ngokubanzi kuzo zonke izihlunu ezahlukeneyo ezifana nezibilini, imithambo yegazi, isibeleko, ulusu, kunye neenwebu zamalungu. Ngokutsho kwedatha evela kwiindawo ezahlukeneyo zomzimba womntu, irekhodwa Uhlobo lwe-I ukuya kwi-III Collagen ratio ifana ne-4: 1 ( ulusu ), 3: 1 ( izitho ), njl.

Olu hlobo lwe-Collagen, olubizwa ngokuba yi-fibrillar, ludala imicu emide, encinci enika izicubu ezinamandla kunye nokuguquguquka. Ngaphezu koko, ikwanceda amanxeba aphole ngokukhawuleza. Ukongezelela, igcina i-architecture yemithambo yegazi kunye namanye amalungu, inceda ukusebenza kwayo ngokufanelekileyo.

➔ Ukusetyenziswa koHlobo lwe-II Collagen

✓ Impilo edibeneyo: Uhlobo lwe-III I-Collagen ayikho into eninzi kumathambo kunye ne-cartilage, kodwa ikhona kwaye inceda ukuxhasa ezinye iintlobo ze-cartilage ukugcina amandla ethambo kunye nempilo.

✓ Impilo yolusu: Uhlobo lwe-III I-Collagen ininzi kakhulu eluswini, njenge-Type I Collagen, kwaye inceda ulusu ukunqanda imigca emihle, ethi kamva ibe yimibimbi. Kwaye, Uhlobo lwe-III Collagen lubumba inethiwekhi yolwakhiwo phantsi kolusu ukugcina ulusu luqinile, kodwa njengoko iCollagen i-elastic, ulusu luhlala lunwebeka.

✓ Impilo yeenwele: I-Tpye III Collagen ibonelela ngezinto eziluhlaza zokubunjwa kweenwele, ngoko ke iphakamisa ukukhula kweenwele kunye namandla. Ngaphezu koko, i-protein ye-Type III nayo ifumaneka kwi-scalp apho iingcambu zeenwele zikhona. Ngamafutshane, ukuthatha i-Type III Collagen supplements kuya kunceda umntu oneenwele ezibuthathaka.

✓ Ukuphiliswa kwenxeba: Uhlobo lwe-III luyiprotheni ye-Collagen yesibini kwimisipha kunye namalungu, kwaye njengoko uyazi, i-Collagen yimagnethi yendalo yokuphilisa iiseli; kwimeko yokulimala, i-Collagen inceda ukwenza izicubu ezitsha ngokukhawuleza.

✓ Ukunganyangeki: Uhlobo lwe-III Collagen lunokunceda ekutyebiseni ukhuseleko ngokuvuselela ukuveliswa kweeseli ezimhlophe zegazi. Ihlala isetyenziselwa izongezelelo zokunyanga izifo ezizimelayo kunye nezinye izifo ze-immune system.

d) Uhlobo lwe-V Collagen kunye nosetyenziso lwayo

"Olu hlobo lweCollagen luhlelwa njenge-fibrillar, lulukwa kwiintsinga ezinde, ezifana nentambo ezinikezela amandla kunye nokuguquguquka kwezicubu-zisebenza noHlobo loku-I kunye noHlobo lwe-III Collagens, idala i-scaffolding yezicubu kunye namalungu."

Uhlobo lwe-V Collagen aluninzi njengezinye iintlobo ezintlanu ezinkulu ze-Collagen, kodwa lwenza imisebenzi ebalulekileyo efana nokwenza ujiko lwamehlo, umaleko wolusu kunye neenwele, kunye nezicubu ze-placenta. Ukusebenza ngaphakathi kwe-matrix ye-extracellular yezicubu ezahlukeneyo, ezinje ngolusu, amathambo, imithambo yegazi kunye ne-placenta, ibonelela ngenkxaso ebalulekileyo yesakhiwo.

➔ Ukusetyenziswa koHlobo lwe-II Collagen

✓ Iinwele kunye neenzipho: Ixhasa impilo kunye nokomelela kweenwele kunye neenzipho.

✓ Impilo yamehlo: Yinto ephambili ye-cornea, igalelo ekugcineni imilo yeliso kunye nokucaca.

✓ Ukomelela koLusu: Uhlobo lwe-V I-Collagen inceda ekugcineni impilo yolusu, igalelo kumandla alo kunye nokunwebeka.

✓ Imithambo yegazi: Uhlobo lwe-V I-Collagen yakha ukwakheka kweendonga zemithambo yegazi, igalelo ekuzinzeni kwayo kunye nokusebenza kakuhle.

✓ Ukuqulunqwa kwezicubu: Uhlobo lwe-collagen lwe-V lunceda ezinye iintlobo ze-collagen ekwenzeni izicubu ezahlukeneyo kunye neengqimba zamalungu, ngoko inceda ekukhuleni kwabo okunempilo.

e) Uhlobo X Collagen & Usetyenziso lwayo

"Uhlobo lwe-X Collagen lubandakanya i-helix emfutshane kathathu ye-Collagen ejikelezwe yimimandla emibini engeyiyo i-collagenous, i-NC2 kunye ne-NC1."

Inceda ekubopheleleni iiminerali ezibalulekileyo, ezifana nekhalsiyam, kwimicu yeCollagen, yomeleza amandla ethambo-ngokwenza oko, inegalelo ekomeleleni kwenkqubo yethu yamathambo.

Ngokungafaniyo nezinye iintlobo ze-Collagen, ayenzi imicu emide kodwa yenza inethiwekhi yeentsinga ezimfutshane. Le nethiwekhi ecacileyo inika amandla kunye nokuguquguquka kwiplani yokukhula kunye nommandla obaliweyo we-articular cartilage.

➔ Ukusetyenziswa koHlobo lwe-II Collagen

Oku kulandelayo kukusetyenziswa kohlobo X lweCollagen;

✓ Indima eKhethekileyo: Nangona ifunyenwe kwimilinganiselo emincinci, umsebenzi wayo owahlukileyo kuphuhliso lwamathambo iqaqambisa ukubaluleka kwayo.

✓ Umbonakalisi woTshintsho: Uhlobo lwe-X Collagen lusebenza njengommakishi ngexesha lokuphuhliswa kwamathambo, ebonisa ukutshintshwa kwe-cartilage ukuya kwithambo eliqinileyo.

✓ Isalathisi sePlate yokuKhula: Ubukho bayo kwiipleyiti zokukhula bubonisa inguqu ebalulekileyo exhasa ukukhula kwamathambo ubude.

✓ Umququzeleli woHlumo: Ngokuncedisa olu tshintsho, Uhlobo lwe-X Collagen luqinisekisa ukuba amathambo akhula zombini ubude kunye namandla, ayimfuneko kwimpilo yamathambo eqinile kunye nokunyaniseka kwesakhiwo.

➔ Isiphelo

Abavelisi be-Collagen emhlabeni jikelele benza izongezo ezikhethekileyo ezijoliswe ekuveliseni uhlobo oluthile lwe-Collagen, njengoHlobo lwe-I okanye uhlobo lwe-II kunye nabanye. Nangona kunjalo, kubalulekile ukuqaphela ukuba abanye bangabavelisi be-Collagen yenkomo, abanye yihagu, ngelixa abanye basebenzisa iinxalenye zezilwanyana ezixubileyo - ezinokuba yingxaki kumgangatho kunye nakwezinye iinkcubeko (ingulube i-Collagen i-haram in Islam).

Nangona kunjalo, thina kwaYasin sijonge ukwenza iCollagen kuzo zonke iintlobo zezilwanyana kodwa kwizikhongozeli ezithile ukuqinisekisa ukuba abathengi bayayifumana le nto bayifunayo. Ke, ukuba ungowabathengisi beeprotheyini okanye ababoneleli ngomgubo weCollagen, sinokuqinisekisa ukuba ufumana i-100% yeemveliso eziyinyani kuthi.