Kwi-1500 BC, eyokuqalacapsulewazalelwa eYiputa.
Ngo-1730, oosokhemesti eVienna baqala ukwenzaiipilisiukusuka kwisitatshi.
Ngowe-1834,capsuleitekhnoloji yokuvelisa yayinelungelo elilodwa lomenzi eParis.
Ngowe-1846, amacandelo amabini nzimacapsuleiteknoloji yokuvelisa yafunyanwa eFrance Patents.
Ngowe-1848, iziqwenga ezimbiniiipilisiiphume.Ukususela ngoko,Khulula amaqokobhe e-capsule eqinilewangena kwihlabathi lezonyango kwaye waba zizikhongozeli zokupakisha amayeza.
Ngowe-1874, ukuveliswa kwemveliso enzimaiipilisi(Hubel) yaqalwa eDetroit, kwaye iimodeli ezahlukeneyo zaziswa ngaxeshanye.
Ngo-1888, uParke-Davis wafumana ilungelo elilodwa lomenzi wechizaii-capsules ezinzimaeDetroit (JB Russell)
Ngowe-1931, uParke-Daviscapsuleisantya sokuvelisa sifikelele kwi-10,000iipilisingeyure (A. Colton)
Njengomathiriyeli wokupakisha ofanelekileyo,Khulula amaqokobhe e-capsule eqinilezisetyenziswa ngokubanzi kumalungiselelo amayeza.Ikakhulu isasazwa ngomgubo, ulwelo, i-semi-solid, i-ointment, iipilisi kunye namanye amalungiselelo.Zinokukhawuleza, zithembeke kwaye ziboliswe ngokukhuselekileyo.Baneenzuzo ezilandelayo:
1) Ubuhle obuhle kwaye kulula ukuginya.
2) I-Masking effect: Iyakwazi ukufihla ubukrakra obungathandekiyo kunye nevumba lechiza, kwaye ikhusele kwaye izinze imixholo engazinzanga.
3) I-bioavailability ephezulu yechiza:Iipilisiayifuni i-adhesive kunye noxinzelelo ngexesha lokulungiselela njengeepilisi kunye neepilisi, ngoko zihlakazeka ngokukhawuleza kwaye zifake kakuhle esiswini kunye namathumbu.
4) Ukukhuselwa ngcono kweemveliso zamachiza: Ngaphandle kobushushu obuphezulu kunye noxinzelelo oluphezulu olulethwa yi-tablet press, imeko yendalo yezityalo zonyango kwizintocapsuleinokugcinwa.
5) Ingenziwa kumalungiselelo okukhululwa okuzinzileyo kunye namalungiselelo adibeneyo:
Ichiza linokukhutshwa ngexesha kunye nendawo (i-enteric-coated, pulsed kunye nezinye iinkqubo zokukhululwa kweziyobisi).Ukuba iyeza lenziwe kuqala libe ngamasuntswana, kwaye emva koko i-gelatin izinto eziluhlaza kunye nezixhobo ezinamazinga ahlukeneyo okukhululwa zisetyenzisiweyo, umphumo wexesha kunye nokukhululwa kwendawo kunokufezekiswa.Ngoko ke,iipilisiziifomu zedosi efanelekileyo kuphuhliso lwamalungiselelo okukhutshwa okuzinzileyo kunye namalungiselelo adibeneyo.
I-6) Umyalelo kunye nenkqubo yokulungiselela ilula, ilungele ushishino kunye ne-automation Production.
Ixesha lokuposa: Aug-24-2021